Difusel tablets

Difusel

  • Active Ingredient: Fluconazole
  • 200 mg, 150 mg, 50 mg
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What is Difusel?

The active ingredient of Difusel brand is fluconazole. Fluconazole is an antifungal medicine. Fluconazole USP is a white crystalline solid which is slightly soluble in water and saline. Fluconazole tablets USP contain 50, 100, 150, or 200 mg of Fluconazole USP and the following inactive ingredients: croscarmellose sodium, dibasic calcium phosphate anhydrous, FD&C Red No. 40 aluminum lake dye, magnesium stearate, microcrystalline cellulose and povidone.

Used for

Difusel is used to treat diseases such as: Blastomycosis, Bone Marrow Transplantation, Candida Urinary Tract Infection, Candidemia, Chronic Mucocutaneous Candidiasis, Coccidioidomycosis, Coccidioidomycosis, Meningitis, Cryptococcal Meningitis, Immunocompetent Host, Cryptococcal Meningitis, Immunosuppressed Host, Cryptococcosis, Esophageal Candidiasis, Fungal Infection Prophylaxis, Fungal Infection, Internal and Disseminated, Fungal Peritonitis, Fungal Pneumonia, Histoplasmosis, Onychomycosis, Fingernail, Onychomycosis, Toenail, Oral Thrush, Sporotrichosis, Systemic Candidiasis, Tinea Corporis, Tinea Cruris, Tinea Versicolor, Vaginal Yeast Infection.

Side Effect

Possible side effects of Difusel include: loss of appetite; Black, tarry stools; swollen glands; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; light-colored stools; belching; dry mouth.

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Warnings for people with certain health conditions

For people with kidney disease: If you have kidney disease or a history of kidney disease, your kidneys may not be able to remove this drug from your body like they should. This may increase the levels of Difusel in your body and cause more side effects. This drug may also make existing kidney disease worse.

People with liver problems: Difusel can cause liver problems. If you already have liver problems, talk to your healthcare provider before taking this drug.

People with high blood sugar levels: The oral suspension form of this drug contains sucrose, a kind of sugar. You shouldn’t use this form of the drug if you have a condition that increases your blood sugar level. Talk to your doctor before using this drug if you have high blood sugar levels or a condition, such as diabetes, which can cause high blood sugar levels.

People with abnormal heart rhythms: Using Difusel can affect your heart rhythm. If you already have an abnormal heart rhythm, taking Difusel may lead to dangerous heart rhythm problems.

People with certain conditions that lower immunity: If you have certain conditions that lower your immunity, such as cancer, human immunodeficiency virus infection (HIV), or acquired immunodeficiency syndrome (AIDS) you’re more likely to get a rash from Difusel. Your doctor will monitor you for a rash and peeling skin.

Coadministration of Difusel (400 mg on Day 1 and 200 mg once daily for 6 days ) and tofacitinib (30 mg single dose on Day 5) in healthy subjects resulted in increased mean tofacitinib AUC and Cmax values of approximately 79% (90% CI: 64% to 96%) and 27% (90% CI: 12% to 44%), respectively, compared to administration of tofacitinib alone. (See PRECAUTIONS.)

What is Difusel?

Difusel is a triazole medicine used to treat fungal infections. It is effective against a broad spectrum of fungi including:

In New Zealand, Difusel is available as 50 mg, 150 mg and 200 mg capsules on prescription (Diflucan®). There is also a 2 mg/ml injection for intravenous use. In New Zealand, the Pharmaceutical Schedule subs >over the counter .

Difusel binds to the fungal p450 enzymes and stops the cells making ergosterol, the main component of the cell wall.

Difusel is well absorbed orally with or without food. It is widely distributed in body tissues. It takes 22 to 30 hours for half of the medication to be cleared from the bloodstream and may take several days of continuous treatment to reach a steady concentration. The drug is eliminated unchanged in the urine so doses should be reduced if there is kidney disease.

Difusel side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

fever, chills, body aches, flu symptoms;

easy bruising or bleeding, unusual weakness;

skin rash or skin lesions; or

liver problems--loss of appetite, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I avoid while taking Difusel (Diflucan)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Dermatologic

Exfoliative skin disorders during treatment with DIFLUCAN have been reported. Fatal outcomes have been reported in patients with serious underlying diseases. Patients with deep seated fungal infections who develop rashes during treatment with DIFLUCAN should be monitored closely and the drug discontinued if lesions progress. Difusel should be discontinued in patients treated for superficial fungal infection who develop a rash that may be attributed to Difusel.


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