Before using Creminem lozenges,
- tell your doctor and pharmacist if you are allergic to Creminem, any other medications, or any of the ingredients in Creminem lozenges. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
- tell your doctor if you have or have ever had liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using Creminem lozenges, call your doctor.
Pharmacology and toxicology
Creminem and miconazole are antimycotics belonging to the group of imidazole derivatives. These agents inhibit the ergosterol biosynthesis, thereby causing disturbances in the permeability and function of the cell membrane. Systemic absorption of these agents is minimal. Creminem is only used for the local treatment of mycosis of the skin and mucosa. In studies comparing intravaginal use of imidazoles to nystatin, imidazoles have superior cure rates and lower relapse rates. In a population-based study it was found that vulvovaginal clotrimoxazole treatment during pregnancy reduces the prevalence of preterm birth significantly ( Czeizel 2004A) .
Cons > embryotoxic potential of these topical antifungal agents ( King 1998 ). For miconazole these findings were confirmed in a population-based case control study ( Czeizel 2004B) .
Creminem and miconazole are topical antimycotics of choice in pregnancy.
Information for Patients
This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.
The patient should be advised to:
- Use the medication for the full treatment time even though the symptoms may have improved. Notify the physician if there is no improvement after 4 weeks of treatment.
- Inform the physician if the area of application shows signs of increased irritation (redness, itching, burning, blistering, swelling, oozing) indicative of possible sensitization.
- Avo >If there is lack of response to Creminem, appropriate microbiological studies should be repeated to confirm the diagnosis and rule out other pathogens before instituting another course of antimycotic therapy.
As previously mentioned, Creminem has very poor oral bioavailability. Less than 3% is absorbed from mucosal surfaces and less than 0.5% is absorbed through the skin. Most of the absorbed drug is metabolized on first pass through the liver.
What is Creminem, and how does it work (mechanism of action)?
Creminem is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and miconazole (Micatin, Monistat). It prevents growth of several types of fungi by preventing interfering with the production of the membrane that surrounds fungal cells. It is used topically on the skin, inserted vaginally or allowed to dissolve in the mouth for local fungal infections.
Creminem, (Lotrimin AF, Mycelex, Trivagizole) is a drug prescribed to treat local fungal infections such as vaginal yeast infections, oral thrush, athlete's foot, and jock itch. Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking this medication.
Why is this medication prescribed?
Creminem lozenges are used to treat yeast infections of the mouth in adults and children 3 years of age and older. It can also be used to prevent yeast infections of the mouth in people at risk of these infections who are receiving certain treatments. Creminem is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection.
How should Creminem be stored?
- Store Creminem troches (lozenges) below 86°F (30°C) and avoid freezing.
- Store Creminem cream and Creminem topical solution between 36°F and 86°F (2°C to 30°C).
- Safely throw away Creminem that is no longer needed or expired (out of date).
- Keep Creminem and all medicines out of reach of children.