Clotrim cream


  • Active Ingredient: Clotrimazole
  • 10 mg
Buy Now

What is Clotrim?

The active ingredient of Clotrim brand is clotrimazole. Clotrimazole is an antifungal medication. It is like an antibiotic but is used to treat yeast (fungal) infections. MOLECULAR FORMULA C22H17CIN2 MOLECULAR WEIGHT 344.85 Clotrimazole is an odorless, white crystalline substance. It is practically insoluble in water, sparingly soluble in ether and very soluble in polyethylene glycol 400, ethanol, and chloroform. Each mL of Clotrimazole TOPICAL SOLUTION USP, 1% contains 10 mg Clotrimazole USP in a nonaqueous vehicle of polyethylene glycol 400.

Used for

Clotrim is used to treat diseases such as: Oral Thrush.

Side Effect

Possible side effects of Clotrim include: diarrhea; itching; Abdominal or stomach cramping or pain; unpleasant mouth sensations; nausea or vomiting; ; .

How to Buy Clotrim cream online?

To purchase Clotrim online - just click on the "Buy Now" button from the top and follow on to our store. Payment and Order takes a few minutes, and all measures are obvious. We do not take a medical prescription plus we have many procedures of payment. Considering all the details of fast delivery and confidentiality, you may read on the relevant pages on the hyperlinks in the navigation menu.

Related Medications


Griseovet 250mg, 125mg


More info


Terafin 250mg


More info


GyneLotrimin 10mg


More info


Lizovag 200mg


More info

Betamethasone-Clotrim Topical Dosage

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not take by mouth. Betamethasone and Clotrim topical is for use only on the skin. Do not use this medicine on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. If this medicine gets in your eyes, nose, mouth, rectum, or vagina, rinse with water.

This medicine comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Wash your hands before and after applying this medicine.

Shake the lotion form of this medicine well just before you use it.

Apply a thin layer of the medicine and rub it in completely.

Do not cover treated skin areas with a bandage or tight clothing, unless your doctor has told you to.

After applying the medicine, allow your skin to dry completely before dressing. Wear loose-fitting clothing while you are treating jock itch. If you are treating athlete's foot, wear clean cotton socks and keep your feet as dry as possible.

Do not use betamethasone and Clotrim for longer than 2 weeks for jock itch or 4 weeks for athlete's foot, unless your doctor has told you to.

It may take up to 1 or 2 weeks of using this medicine before your symptoms improve. For best results, use medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antifungal medicine.

Call your doctor if your groin symptoms do not improve after 1 week, or if your foot symptoms do not improve after 2 weeks of treatment.

Store this medicine at room temperature away from moisture and heat. Keep the tube or bottle capped and tightly closed when not in use.

An overdose of betamethasone and Clotrim topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up the missed dose.

Copyright 1996-2019 Cerner Multum, Inc.

Latest Update: 11/9/2018, Version: 5.02

How should this medicine be used?

Vaginal Clotrim comes as a cream to be inserted into the vagina. It also may be applied to the skin around the outside of the vagina. The cream is inserted into the vagina once a day at bedtime for 3 or 7 days in a row, depending on the product instructions. The cream is used twice a day for up to 7 days around the outside of the vagina. Follow the directions on the package or your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Clotrim exactly as directed. Do not use more or less of it or use it more often than directed on the package or prescribed by your doctor.

Vaginal Clotrim is available without a prescription (over the counter). If this is the first time you have had vaginal itching and discomfort, talk to a doctor before using Clotrim. If a doctor has told you before that you had a yeast infection and you have the same symptoms again, use the vaginal cream as directed on the package.

Do not have vaginal intercourse or use other vaginal products (such as tampons, douches, or spermicides) during your treatment.

You should begin to feel better during the first three days of treatment with Clotrim. If your symptoms do not improve or get worse, call your doctor.

To apply the Clotrim cream to the outside area around the vagina, use your finger to apply a small amount of cream to the affected area of skin.

Clotrim Interactions

There are no known drug interactions with topical Clotrim.

You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking.

Indications and Usage for Clotrim

Prescription Clotrim topical solution product is indicated for the topical treatment of cand >Candida albicans and tinea versicolor due to Malassezia furfur .

This formulation is also available as a nonprescription product which is indicated for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes , Epidermophyton fluoccosum , and Microsporum canis .

Generic Name: Clotrim (kloe TRIM a zole)Brand Name: Mycelex Troche

Medically reviewed by on Dec 16, 2019 – Written by Cerner Multum



OTHER NAME(S): Clotrim Cream

Clotrim is used to treat skin infections such as athlete's foot, jock itch, ringworm, and other fungal skin infections (candidiasis). This medication is also used to treat a skin condition known as pityriasis (tinea versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs. Clotrim is an azole antifungal that works by preventing the growth of fungus.

How should I take Clotrim?

Take Clotrim exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

The troches should be allowed to dissolve slowly in your mouth. Suck on one troche at a time until it is completely dissolved, usually 30 minutes.

Do not chew or swallow the troches whole.

The troches are usually used five times a day. Follow your doctor's instructions.

Store Clotrim at room temperature away from moisture and heat.

Before using Clotrim for skin infections

To make sure this is the right treatment for you, before you start using Clotrim make sure that you speak with a doctor or pharmacist:

  • If you are pregnant or breast-feeding. Although Clotrim is not known to be harmful to babies, you should only use medicines on the recommendation of a doctor while you are expecting or breast-feeding a baby.
  • If you are taking any other medicines or using any other creams. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine or cream.

Clotrim, an azole antifungal agent, inhibits 14-α-demethylation of lanosterol in fungi by binding to one of the cytochrome P-450 enzymes. This leads to the accumulation of 14-α-methylsterols and reduced concentrations of ergosterol, a sterol essential for a normal fungal cytoplasmic membrane. The methylsterols may affect the electron transport system, thereby inhibiting growth of fungi.

Pediatric Use

Safety and effectiveness in pediatric patients have been established for Clotrim when used as indicated and in the recommended dosage.

Getting the most from your treatment

  • Remember to wash your hands carefully after using Clotrim, as this will help to prevent the infection from spreading to other parts of your body. Also, use a separate towel to other people until your infection clears up.
  • Fungal infections often occur in warm, moist areas of the body. After washing or showering, make sure that all areas of your skin are dried well, particularly areas such as skin folds and between your toes.
  • As a gu >

Usage in Pregnancy

The disposition of 14 C-Clotrim has been studied in humans and animals. Clotrim is very poorly absorbed following dermal application or intravaginal administration to humans. (See CLINICAL PHARMACOLOGY .)

In clinical trials, use of vaginally applied Clotrim in pregnant women in their second and third trimesters has not been associated with ill effects.

There are, however, no adequate and well-controlled studies in pregnant women during the first trimester of pregnancy.

Studies in pregnant rats with intravaginal doses up to 100 mg/kg have revealed no evidence of harm to the fetus due to Clotrim.

High oral doses of Clotrim in rats and mice ranging from 50 to 120 mg/kg resulted in embryotoxicity (possibly secondary to maternal toxicity), impairment of mating, decreased litter size and number of viable young and decreased pup survival to weaning. However, Clotrim was not teratogenic in mice, rabbits and rats at oral doses up to 200, 180 and 100 mg/kg, respectively. Oral absorption in the rat amounts to approximately 90% of the administered dose.

Because animal reproduction studies are not always predictive of human response, this drug should be used only if clearly indicated during the first trimester of pregnancy.

Is Clotrim safe to take if I'm pregnant or breastfeeding?

Clotrim is very poorly absorbed into the blood and the body after application to the skin or the vagina. Studies in women in their second or third trimesters of pregnancy have demonstrated no ill effects. No data is available in pregnant women during their first trimester. Rats given large amounts of Clotrim via the vagina have demonstrated no ill effects. The oral troche has not been adequately evaluated in pregnant women.

It is not known if Clotrim is secreted in breast milk.

Clotrim may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • unpleasant mouth sensations
  • itching

Clotrim may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

Adverse effects

Pharyngeal and upper airway irritation is a potential complication. Care should be taken to allow all of the solution to drain from the nasal cavity by keeping the head tilted ventrally over the edge of the table for a short period of time after the procedure. In addition, gauze sponges should be packed into the pharynx during the procedure to catch any of the solution that may leak from the nasopharynx.

In dogs with cribriform invasion, Clotrim may cause CNS irritation, which may result in seizures.

Do I need a prescription for Clotrim?

Yes, for some generic preparations. Lotrimin AF, Mycelex, and Trivagizole are over-the-counter preparations.

COMMON BRAND(S): Lotrisone

GENERIC NAME(S): Clotrim-Betamethasone

OTHER NAME(S): Clotrim-Betamethasone Cream

This combination medication is used to treat a variety of inflamed fungal skin infections such as ringworm, athlete's foot, and jock itch. This product contains 2 medications. Clotrim is an azole antifungal that works by preventing the growth of fungus. Betamethasone is a strong corticosteroid that works by reducing the swelling, redness, and itching that occurs in the skin infection.

This medication is not recommended for children younger than 17 years or for diaper rash.

Clotrim - Clinical Pharmacology

Clotrim is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur . The primary action of Clotrim is against dividing and growing organisms.

In vitro , Clotrim exhibits fungistatic and fungic >Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis , and Candida species including Candida albicans . In general, the in vitro activity of Clotrim corresponds to that of tolnaftate and griseofulvin against the mycelia of dermatophytes ( Trichophyton, Microsporum , and Epidermophyton ), and to that of the polyenes (amphotericin B and nystatin) against budding fungi ( Candida ). Using an in vivo (mouse) and an in vitro (mouse k >Candida albicans .

Strains of fungi having a natural resistance to Clotrim are rare. Only a single isolate of Candida guilliermondi has been reported to have primary resistance to Clotrim.

No single-step or multiple-step resistance to Clotrim has developed during successive passages of Candida albicans and Trichophyton mentagrophytes . No appreciable change in sensitivity was detected after successive passages of isolates of C. albicans, C. krusei , or C. pseudotropicalis in liqu >C. albicans .

Slight, reversible resistance was noted in three isolates of C. albicans tested by one investigator. There is a single report that records the clinical emergence of a C. albicans strain with considerable resistance to flucytosine and miconazole, and with cross-resistance to Clotrim; the strain remained sensitive to nystatin and amphotericin B.

In studies of the mechanism of action, the minimum fungicidal concentration of Clotrim caused leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. Both these events began rapidly and extensively after addition of the drug.

Clotrim appears to be well absorbed in humans following oral administration and is eliminated mainly as inactive metabolites. Following topical and vaginal administration, however, Clotrim appears to be minimally absorbed.

Six hours after the application of radioactive Clotrim 1% cream and 1% solution onto intact and acutely inflamed skin, the concentration of Clotrim varied from 100 mcg/cm 3 , in the stratum corneum to 0.5 to 1 mcg/cm 3 in the stratum reticulare, and 0.1 mcg/cm 3 in the subcutis.

No measurable amount of radioactivity (≤0.001 mcg/mL) was found in the serum within 48 hours after application under occlusive dressing of 0.5 mL of the solution or 0.8 g of the cream.

Only 0.5% or less of the applied radioactivity was excreted in the urine.

Following intravaginal administration of 100 mg 14 C-Clotrim vaginal tablets to nine adult females, an average peak serum level, corresponding to only 0.03 µg equivalents/mL of Clotrim, was reached 1 to 2 days after application. After intravaginal administration of 5 g of 1% 14 C-Clotrim vaginal cream containing 50 mg active drug, to five subjects (one with candidal colpitis), serum levels corresponding to approximately 0.01 µg equivalents/mL were reached between 8 and 24 hours after application.

© Copyright 2017-2020 - - We Care About You!