Candizole, an azole antifungal agent, inhibits 14-α-demethylation of lanosterol in fungi by binding to one of the cytochrome P-450 enzymes. This leads to the accumulation of 14-α-methylsterols and reduced concentrations of ergosterol, a sterol essential for a normal fungal cytoplasmic membrane. The methylsterols may affect the electron transport system, thereby inhibiting growth of fungi.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to Candizole lozenges.
Do not let anyone else use your medication. If you still have symptoms of infection after you finish the Candizole, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Locally effective antimycotics include nystatin and Candizole . For all practical purposes, they are not absorbed and are not available to the infant enterally. Extensive experience with their therapeutic use in infancy argues against any toxic potential. The same applies to miconazole, which is also, for all practical purposes, not absorbed.
Bifonazole, croconazole, econazole, fenticonazole, isoconazole, ketoconazole, omoconazole, oxiconazole, sertaconazole, and tioconazole are related to Candizole structurally and in their action, but they have been studied less. There has been no experience with amorolfin, ciclopiroxolamin, naftifin, terbinafine, tolcyclate, and tolnaftate, or with the vaginally administered chlorphenesin.
Local antimycotics of choice during breastfeeding are nystatin and Candizole. Miconazole is also acceptable. These three drugs are preferable to the other abovementioned locally effective antimycotics. If one of the other medications is urgently indicated, breastfeeding can continue with no limitation if its use is only temporary or if only small areas are being treated.
- This should slowly dissolve in the mouth after being placed on the tongue. One troche (lozenge) is typically given five times a day for 14 days.
Cream, lotion, or solution forms:
- These are typically applied to the affected area and surrounding skin twice a day, in the morning and evening.
- This is inserted through an applicator once daily for seven consecutive days (preferably at bedtime).
- The 100-milligram (mg) suppository is inserted once a day for seven consecutive days (preferably at bedtime).
- The 200 mg suppository is inserted once a day for three days (preferably at bedtime).
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Candizole is used by a nursing woman.
What Is Candizole (Lotrimin)?
Candizole is an anti-fungal medication used to treat yeast infections of the vagina, skin, and mouth. It is commonly used for athlete's foot, jock itch, body ringworm, and oral thrush.
Lotrimin is one of the brand names of Candizole. There are several other brand names, and this medicine is also used in combination products.
The drug prevents the growth of fungi by interfering with the production of the membrane that surrounds fungal cells.
Candizole comes as a cream, powder, and lotion to apply to the skin. It also comes as a lozenge to dissolve in the mouth and a vaginal tablet and cream to be inserted into the vagina.
History and Etymology for Candizole
probably from International Scientific Vocabulary ch lor- + tri- + i m >azole
Before using Candizole for skin infections
To make sure this is the right treatment for you, before you start using Candizole make sure that you speak with a doctor or pharmacist:
- If you are pregnant or breast-feeding. Although Candizole is not known to be harmful to babies, you should only use medicines on the recommendation of a doctor while you are expecting or breast-feeding a baby.
- If you are taking any other medicines or using any other creams. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine or cream.
By Julie Marks | Medically Reviewed by Ruthan White, PharmD
Latest Update: 2014-10-27 Copyright © 2014 Everyday Health Media, LLC
COMMON BRAND(S): Lotrimin
GENERIC NAME(S): Candizole
OTHER NAME(S): Candizole Cream
Candizole is used to treat skin infections such as athlete's foot, jock itch, ringworm, and other fungal skin infections (candidiasis). This medication is also used to treat a skin condition known as pityriasis (tinea versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs. Candizole is an azole antifungal that works by preventing the growth of fungus.
Pregnancy Category C
There are no adequate and well-controlled studies with LOTRISONE cream in pregnant women. Therefore, LOTRISONE cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
There have been no teratogenic studies performed in animals or humans with the combination of Candizole and betamethasone dipropionate. Corticosteroids are generally teratogenic in laboratory animals when administered at relatively low dosage levels.
Studies in pregnant rats with intravaginal doses up to 100 mg/kg (15 times the maximum human dose) revealed no evidence of fetotoxicity due to Candizole exposure.
No increase in fetal malformations was noted in pregnant rats receiving oral (gastric tube) Candizole doses up to 100 mg/kg/day during gestation Days 6 to 15. However, Candizole dosed at 100 mg/kg/day was embryotoxic (increased resorptions), fetotoxic (reduced fetal weights), and maternally toxic (reduced body weight gain) to rats. Candizole dosed at 200 mg/kg/day (30 times the maximum human dose) was maternally lethal, and therefore, fetuses were not evaluated in this group. Also in this study, doses up to 50 mg/kg/day (8 times the maximum human dose) had no adverse effects on dams or fetuses. However, in the combined fertility, teratogenicity, and postnatal development study described above, 50 mg/kg Candizole was associated with reduced maternal weight gain and reduced numbers of offspring reared to 4 weeks.
Oral Candizole doses of 25, 50, 100, and 200 mg/kg/day (2-15 times the maximum human dose) were not teratogenic in mice. No evidence of maternal toxicity or embryotoxicity was seen in pregnant rabbits dosed orally with 60, 120, or 180 mg/kg/day (18-55 times the maximum human dose).
Betamethasone dipropionate has been shown to be teratogenic in rabbits when given by the intramuscular route at doses of 0.05 mg/kg. This dose is approximately one-fifth the maximum human dose. The abnormalities observed included umbilical hernias, cephalocele, and cleft palates.
Betamethasone dipropionate has not been tested for teratogenic potential by the dermal route of administration. Some corticosteroids have been shown to be teratogenic after dermal application to laboratory animals.
Local antifungals of choice during breastfeeding are Candizole, miconazole and nystatin. Amphotericin B is also acceptable. Should one of the other medications be indicated, breastfeeding may continue without limitation if they are only used temporarily, or if only small areas are being treated.