Axasol cream

Axasol

  • Active Ingredient: Clotrimazole
  • 10 mg
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What is Axasol?

The active ingredient of Axasol brand is clotrimazole. Clotrimazole is an antifungal medication. It is like an antibiotic but is used to treat yeast (fungal) infections. MOLECULAR FORMULA C22H17CIN2 MOLECULAR WEIGHT 344.85 Clotrimazole is an odorless, white crystalline substance. It is practically insoluble in water, sparingly soluble in ether and very soluble in polyethylene glycol 400, ethanol, and chloroform. Each mL of Clotrimazole TOPICAL SOLUTION USP, 1% contains 10 mg Clotrimazole USP in a nonaqueous vehicle of polyethylene glycol 400.

Used for

Axasol is used to treat diseases such as: Oral Thrush.

Side Effect

Possible side effects of Axasol include: diarrhea; unpleasant mouth sensations; Abdominal or stomach cramping or pain; itching; nausea or vomiting; ; .

How to Buy Axasol cream online?

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What brand names are available for Axasol?

  • Lotrimin AF , Mycelex, Trivagizole
  • Gyne-Lotrimin (DC), Alevazol, Desenex, Lotrimin have been discontinued.

Oropharyngeal cand > Mild disease can be treated with Axasol troches (one 10 mg troche five times daily) or nystatin suspension (400 000–600 000 units 4 times daily). Oral fluconazole (100–200 mg/day for 7–14 days orally) is recommended for moderate-to-severe disease. It has been shown that a single dose of fluconazole of 750 mg was as efficacious as a full 2-week course of 150 mg daily for the treatment of oropharyngeal candidiasis. 32 Recommended therapy for refractory disease includes itraconazole solution (200 mg/day for 7–14 days orally); voriconazole (200 mg/day orally); posaconazole (400 mg/day orally) or amphotericin B oral suspension. 33 Intravenous echinocandin or amphotericin B deoxycholate at 0.3 mg/kg per day were also shown to be effective and may be used as last-resort therapy in patients with refractory disease.

Although suppressive therapy is effective for the prevention of recurrent infections, to reduce the likelihood of development of antifungal resistance it should be used only if the recurrences are frequent or disabling. Denture-related disease may require thorough disinfection of the denture for definitive cure. Oral thrush caused by inhaled steroids can be prevented by rinsing with saline after use.

How to use Axasol solution as ear drops

  1. Wash your hands. Clean your ear gently with warm water and then pat it dry.
  2. Lie down, or tilt your head a little, so that the affected ear is facing upwards.
  3. Gently pull your earlobe downwards to straighten the ear canal.
  4. Hold the dropper from the bottle near to your ear and apply enough pressure to release two or three drops of solution into your ear.
  5. Keep your ear facing upwards for a few minutes to allow the solution to come into contact with the affected area.
  6. Repeat the process in your other ear if both ears are affected.
  7. Replace the bottle dropper.
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Pediatric Use

Safety and effectiveness in pediatric patients have been established for Axasol when used as indicated and in the recommended dosage.

What is Axasol?

Axasol is an antifungal that has different uses in over-the-counter (OTC) medicines. Depending on the dose and form, Axasol can be used to treat symptoms associated with skin fungus infections such as athlete’s foot, jock itch, and ringworm. Axasol can also be used to treat vaginal yeast infections.

Usage in Pregnancy

The disposition of 14 C-Axasol has been studied in humans and animals. Axasol is very poorly absorbed following dermal application or intravaginal administration to humans. (See CLINICAL PHARMACOLOGY .)

In clinical trials, use of vaginally applied Axasol in pregnant women in their second and third trimesters has not been associated with ill effects.

There are, however, no adequate and well-controlled studies in pregnant women during the first trimester of pregnancy.

Studies in pregnant rats with intravaginal doses up to 100 mg/kg have revealed no evidence of harm to the fetus due to Axasol.

High oral doses of Axasol in rats and mice ranging from 50 to 120 mg/kg resulted in embryotoxicity (possibly secondary to maternal toxicity), impairment of mating, decreased litter size and number of viable young and decreased pup survival to weaning. However, Axasol was not teratogenic in mice, rabbits and rats at oral doses up to 200, 180 and 100 mg/kg, respectively. Oral absorption in the rat amounts to approximately 90% of the administered dose.

Because animal reproduction studies are not always predictive of human response, this drug should be used only if clearly indicated during the first trimester of pregnancy.

What should I tell my health care provider before taking Axasol?

Before taking Axasol, tell your health care provider:

  • If you are allergic to Axasol or any other medicines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems.
  • About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take pills.
  • If you are pregnant or plan to become pregnant. The different formulations of Axasol have different usage recommendations during pregnancy. Axasol cream and Axasol topical solution should be used during the first trimester of pregnancy only if clearly indicated. In clinical trials, use of the cream and topical solution during the second and third trimesters was not associated with ill effects. Whether Axasol troche (lozenges) can harm an unborn baby is unknown. The lozenges should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus .
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Ask your health care provider if there are interactions between Axasol and the other medicines you take.

Ask your health care provider about possible side effects from Axasol. Your health care provider will tell you what to do if you have side effects.

How much Axasol can you take?

Different types of products containing this active ingredient have different strengths. That’s why it is always important to read and follow the Drug Facts label. Most medicines warn against use of an active ingredient for longer than 7-10 days. Stop use and ask a doctor if symptoms persist.

Mechanism Of Action

Axasol is an azole antifungal .

Betamethasone dipropionate is a corticosteroid. Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action for the treatment of tinea pedis, tinea cruris and tinea corporis is unknown.

Axasol Interactions

There are no known drug interactions with topical Axasol.

You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking.

Dosage Forms And Strengths

Cream, 1%/0.05%. Each gram of LOTRISONE cream contains 10 mg of Axasol and 0.643 mg of betamethasone dipropionate (equivalent to 0.5 mg of betamethasone) in a white to off-white cream base.

Summary

Axasol, (Lotrimin AF, Mycelex, Trivagizole) is a drug prescribed to treat local fungal infections such as vaginal yeast infections, oral thrush, athlete's foot, and jock itch. Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking this medication.

Azole Drugs Used Topically

The topical azoles include miconazole, Axasol , butoconazole, terconazole, tioconazole, sertaconazole, sulconazole, oxiconazole, econazole, efinaconazole, luliconazole, and ketoconazole. Miconazole and Axasol are of special interest in oral candidiasis as discussed next.

Axasol is an imidazole antifungal drug used for various mucosal and cutaneous infections. The antifungal spectrum and mechanism of action are similar to the other imidazole derivatives. For the treatment of oral candidiasis, Axasol is available as a 10-mg troche (see Table 34-2 ). Slow dissolution in the mouth results in the binding of Axasol to the oral mucosa, from which it is gradually released to maintain at least fungistatic concentrations for several hours. The swallowed drug is variably but poorly absorbed. It is metabolized in the liver and eliminated in the feces along with the unabsorbed drug.

One troche dissolved in the mouth five times a day for 2 weeks is the standard regimen for oropharyngeal candidiasis. Patient compliance is believed to be enhanced by the more pleasant taste of Axasol compared with nystatin. Axasol also appears to be highly effective and is the drug of choice for the treatment of oral candidiasis in patients with AIDS. For cutaneous candidiasis and dermatophytoses, a 1% cream or lotion is equivalent to topical miconazole.

Adverse oral effects associated with topical Axasol, though unlikely, may include oral burning, altered taste, and xerostomia. Occasionally, minor gastrointestinal upset may follow oral ingestion of the drug.

Miconazole (see Fig. 34-3 ) is an imidazole that is useful against cutaneous candidiasis and vulvovaginitis caused by C. albicans; these conditions usually respond rapidly and reliably to a 2% miconazole nitrate cream. A buccal tablet is available for treatment of oral candidiasis. The tablet is pressed on the gingiva in the canine fossa above tooth #8 or #9 (see Table 34-2 ). It adheres there and releases the drug over a period of about 6 hours. Adverse oral effects are similar to those of Axasol, with the additional possibility of gingival irritation and pain at the application site. Other topical uses of miconazole are for the treatment of cutaneous infections caused by Epidermophyton, Microsporum, and Trichophyton.

Terconazole, a member of the triazole antifungals, is supplied in a vaginal suppository for vaginal candidiasis. Butoconazole and tioconazole are imidazoles that are also used topically for vulvovaginitis. Oxiconazole, econazole, sertaconazole, and sulconazole are imidazoles used topically for infections caused by dermatophytes ( Table 34-3 ).

TABLE 34-3 . Topical Use of Antifungal Drugs

Overdosage

Acute overdosage with topical application of Axasol is unlikely and would not be expected to lead to a life-threatening situation.

Axasol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • unpleasant mouth sensations
  • itching

Axasol may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

How to store Axasol

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

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