Adenosan cream


  • Active Ingredient: Ketoconazole
  • 200 mg
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What is Adenosan?

The active ingredient of Adenosan brand is ketoconazole. Ketoconazole is an antifungal medication that fights infections caused by fungus. Molecular Formula: C26H28Cl2N4O4 Molecular Weight: 531.43 After a single topical application to the chest, back and arms of normal volunteers, systemic absorption of ketoconazole was not detected at the 5 ng/mL level in blood over a 72-hour period. Two dermal irritancy studies, a human sensitization test, a phototoxicity study and a photoallergy study conducted in 38 male and 62 female volunteers showed no contact sensitization of the delayed hypersensitivity type, no irritation, no phototoxicity and no photoallergenic potential due to Ketoconazole Cream, 2%.

Used for

Adenosan is used to treat diseases such as: Blastomycosis, Chromomycosis, Chronic Mucocutaneous Candidiasis, Coccidioidomycosis, Dermatophytosis, Esophageal Candidiasis, Histoplasmosis, Onychomycosis, Fingernail, Onychomycosis, Toenail, Oral Thrush, Paracoccidioidomycosis, Tinea Corporis, Tinea Versicolor, Vaginal Yeast Infection.

Side Effect

Possible side effects of Adenosan include: black, tarry stools; vision changes; unusual bleeding or bruising; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; dark urine.

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What is Adenosan topical?

Adenosan topical (for the skin) is an antifungal medicine used to treat infections such as athlete's foot, jock itch, ringworm, and seborrhea (dry, flaking skin or dandruff).

Adenosan topical is also used to treat a fungal infection called pityriasis, which causes scaly discolored patches on the skin of the neck, chest, arms, or legs.

Adenosan topical may also be used for purposes not listed in this medication guide.

Adenosan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • changes in hair texture
  • blisters on scalp
  • dry skin
  • itching
  • oily or dry hair or scalp
  • irritation, itching, or stinging in the place where you applied the medication

Why is this medication prescribed?

Adenosan cream is used to treat tinea corporis (ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes), tinea versicolor (fungal infection of the skin that causes brown or light colored spots on the chest, back, arms, legs, or neck), and yeast infections of the skin. Prescription Adenosan shampoo is used to treat tinea versicolor. Over-the-counter Adenosan shampoo is used to control flaking, scaling, and itching of the scalp caused by dandruff. Adenosan is in a class of antifungal medications called imidazoles. It works by slowing the growth of fungi that cause infection.


Adenosan is a common treatment for psoriasis, another inflammatory skin disease that causes skin flaking, skin plaques, and redness. Yeast-like fungus often infects these skin plaques. Prescription Adenosan may be needed for psoriasis flares.

What should I avoid while using Adenosan topical?

Do not get this medicine in your eyes. If contact does occur, rinse with water.

Avoid covering treated skin areas with tight-fitting, synthetic clothing (such as nylon or polyester) that doesn't allow air to circulate to your skin. If you are treating your feet, wear clean cotton socks and sandals or shoes that allow for air circulation. Keep your feet as dry as possible.

You may need to avoid sunlight if you are treating pityriasis. Follow your doctor's instructions.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

Avoid using other medications on the areas you treat with Adenosan topical unless your doctor tells you to.

Drug interactions of Adenosan.

Adenosan is a p- glycoprotein inhibitor and can have serious interactions with other medications.

  • Ketonazole should not be taken with the HMG Co-A reductase inhibitor simvastatin, and the dose of atorvastatin should be reduced. Toxicity results in muscle pain and weakness, which may be serious. If long-term treatment with a statin and Adenosan is required, suitable alternatives are fluvastatin, pravastatin and rosuvastatin.
  • It is also contraindicated with the anticoagulant, dabigatran because of the risk of bleeding.

As Adenosan needs acid for its absorption, antacids, H2 antagonists (cimetidine, famotidine, ranitidine) and omeprazole should not be taken for 2 hours after Adenosan.

Adenosan interacts with alcohol rather like disulfiram (Antabuse®) and can cause severe nausea and vomiting.

Adenosan may increase the concentration of these drugs and enhance their effect:

  • Warfarin
  • Methyl prednisolone
  • Cisapride
  • The antihistamines astemizole (Hismanal®) and terfenadine (Teldane®)
  • ciclosporin
  • Midazolam, triazolam
  • Busulfan
  • Antidiabetic sulphonylurea medication (tolbutamide, glibenclamide, gliclazide, glipizide

The following drugs markedly decrease the concentration of Adenosan:

Adenosan is not thought to interact with the oral contraceptive pill.

What is Adenosan (Nizoral)?

Adenosan is an antifungal medication that is used to treat certain infections caused by fungus.

This medicine should be used only when you cannot use other antifungal medications. Adenosan can cause serious harm to your liver that may result in liver transplant or cause death.

Adenosan is not for use in treating fungal infections of the fingernails or toenails. This medicine is also not for use in treating prostate cancer or Cushing syndrome.

Adenosan may also be used for purposes not listed in this medication guide.

What Is Adenosan Topical?

Adenosan topical is an antifungal medication that prevents fungus from growing on your skin.

Adenosan topical is used to treat fungal infections of the skin such as athlete's foot, jock itch, ringworm, and seborrhea (dry, flaking skin).

Adenosan topical is available as a cream, gel, and as a shampoo. The shampoo is used for the treatment of dandruff.

Adenosan topical may also be used for purposes not listed in this medication guide.

You should not use Adenosan topical if you are allergic to it.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antifungal medication.

Do not use bandages or dressings over the treated skin areas, unless your doctor has told you to.

Avoid getting this medication in your eyes, nose, or mouth.

Stop using Adenosan topical and call your doctor if you have severe burning, irritation, redness, pain, or oozing where the medicine is applied.

Adenosan topical gel is flammable. Do not use it while you are smoking or near an open flame.

Do not use this medication on a child younger than 12 years old.

You should not use Adenosan topical if you are allergic to it.

FDA pregnancy category C. It is not known whether Adenosan topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether Adenosan topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. You should not breast-feed if you have applied Adenosan topical to your breast area.

Do not give this medicine to a child younger than 12 years old without medical advice.

What is Adenosan?

Adenosan is a prescription medication that is primarily used to treat fungal infections. Technically, it has been classified pharmacologically as an antifungal drug.

It works by managing different forms of fungal infections such as ringworm, candidiasis, and seborrheic dermatitis, which are all more common amongst people than you’d think.

We did come to learn that treating fungal infections is not the only possible indication of using Adenosan. If you did not know already, Adenosan is a common ingredient that you will find in most hair loss shampoos.

Generic Name: Adenosan (KEE toe KON a zole)Brand Name: Nizoral

Medically reviewed by on Jan 10, 2019 – Written by Cerner Multum


Pharmacologic class: Imidazole

Therapeutic class: Antifungal

Pregnancy risk category C

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