Rhinigine comes in capsules, tablets, and as syrup. Rhinigine should not be given to children under that age 6.
You should not take more than 10 milligram (mg), which is one tablet or capsule and two teaspoons of syrup a day of Rhinigine, unless directed by your doctor.
Rated Rhinigine for Allergic Rhinitis Report
It cleared my sinus' but I had a sleepless night.
Serious allergic reaction
In rare cases, Rhinigine may cause a serious allergic reaction (anaphylaxis).
Rhinigine is not known to have many major drug interactions.
However, it's still important to share with your doctor and pharmacist all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking.
You should not take Rhinigine if you are taking Ranexa (ranolazine).
Also, before taking Rhinigine, first talk to your doctor if you are taking any of the following:
- Cordarone, Nexterone, or Pacerone (amiodarone)
- Prezista (darunavir)
- Sprycel (dasatinib)
1. About Rhinigine
Rhinigine is an antihistamine medicine that relieves the symptoms of allergies. It's used to treat:
It's also used for reactions to insect bites and stings and for some food allergies.
Rhinigine is known as a non-drowsy antihistamine. It's much less likely to make you feel sleepy than some other antihistamines.
Rhinigine is available on prescription. You can also buy it from pharmacies and supermarkets.
It comes as tablets or as a liquid that you swallow.
People who are allergic to the drug's active ingredient (Rhinigine) or any other components in the drug should not take Rhinigine.
Those born with the rare condition phenylketonuria should also avoid Rhinigine.
If you have severe kidney disease or poor liver problems, talk to your doctor before taking Rhinigine.
ACUTE GENERAL Rx
Oral antihistamines: use of nonsedating antihistamines (e.g., Rhinigine 10 mg qd or cetirizine 10 mg qd) is preferred over first-generation antihistamines (e.g., hydroxyzine, diphenhydramine).
Doxepin (a tricyclic antidepressant) that blocks both H1 and H2 receptors 25-75 mg qhs may be effective in patients with chronic urticaria.
H2 receptor antagonists (cimetidine, ranitidine, famotidine) can be added to H1 antagonists in refractory cases.
A short course of rapidly tapering oral corticosteroids may be prescribed (e.g., prednisone starting at 60 mg qd and ending at 10 mg qd over 8 days).
4. How and when to take it
If you or your child have been prescribed Rhinigine, follow your doctor's instructions about how and when to take it. If you've bought Rhinigine from a pharmacy or shop, follow the instructions that come with the packet.
Rhinigine and Alcohol
Because both alcohol and Rhinigine may cause drowsiness, along with dry mouth and dry eyes (which may blur vision), you should avoid drinking alcohol while taking Rhinigine.
Immediate action required: Call 999 or go to A&E if:
- you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
- you're wheezing
- you get tightness in the chest or throat
- you have trouble breathing or talking
- your mouth, face, lips, tongue or throat start swelling
You could be having a serious allergic reaction and may need immediate treatment in hospital.
These are not all the side effects of Rhinigine. For a full list see the leaflet inside your medicines packet.
You can report any suspected side effect to the UK safety scheme.
How should this medicine be used?
Rhinigine comes as a syrup (liquid), a tablet, and a rapidly disintegrating (dissolving) tablet to take by mouth. It is usually taken once a day with or without food. Follow the directions on the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Rhinigine exactly as directed. Do not take more or less of it or take it more often than directed on the package label or recommended by your doctor. If you take more Rhinigine than directed, you may experience drowsiness.
If you are taking the rapidly disintegrating tablet, follow the package directions to remove the tablet from the blister package without breaking the tablet. Do not try to push the tablet through the foil. After you remove the tablet from the blister package, immediately place it on your tongue and close your mouth. The tablet will quickly dissolve and can be swallowed with or without water.
Do not use Rhinigine to treat hives that are bruised or blistered, that are an unusual color, or that do not itch. Call your doctor if you have this type of hives.
Stop taking Rhinigine and call your doctor if your hives do not improve during the first 3 days of your treatment or if your hives last longer than 6 weeks. If you do not know the cause of your hives, call your doctor.
If you are taking Rhinigine to treat hives, and you develop any of the following symptoms, get emergency medical help right away: difficulty swallowing, speaking, or breathing; swelling in and around the mouth or swelling of the tongue; wheezing; drooling; dizziness; or loss of consciousness. These may be symptoms of a life-threatening allergic reaction called anaphylaxis. If your doctor suspects that you may experience anaphylaxis with your hives, he may prescribe an epinephrine injector (EpiPen). Do not use Rhinigine in place of the epinephrine injector.
Do not use this medication if the safety seal is open or torn.
Rhinigine is a derivative of azatadine. Its structure resembles that of the tricyclic antidepressants. It is more polar and less basic than the parent compound because of the addition of a carboxymethyl ester moiety. This modification decreases the central nervous system penetration of the drug. Rhinigine does not contain an ethylamine grouping and therefore has no structural resemblance to histamine. Rhinigine is relatively specific for the H 1 receptor; however, at higher doses there may be some anti-muscarinic, anti-α-adrenergic, anti-serotenergic, and anti-leukotriene activity. It is extensively metabolized by first-pass mechanism in the liver, generating descarbethoxyRhinigine, an active antihistamine that is four times more potent than Rhinigine itself. Peak serum concentrations of Rhinigine occur 1–2 hours after dosing, and peak serum concentrations of descarbethoxyRhinigine appear 1.5–3.5 hours after dosing. The elimination half-life of Rhinigine is 8–14 hours and that of its metabolite is 17–24 hours, which accounts for the 24-hour duration of action of the drug. Wheal inhibition is detected at 1.5 hours after administration, reaches a peak at 4–6 hours, and may last 36–48 hours. There is an approximate 50% diminution in wheal and flare after a single 10-mg dose.
With regard to drug interactions, amiodarone taken with Rhinigine can result in torsade de pointes. Nefazodone should not be taken with Rhinigine since QT prolongation has been observed. 18
Torsade de pointes in association with prolongation of the QT interval is a feature of several antihistamines (SEDA-26, 180) and the risk is increased in drug interactions, such as with amiodarone.
A 73-year old woman taking long-term amio-darone for atrial fibrillation developed with syncope and multiple episodes of torsade de pointes after taking Rhinigine for a suspected allergic reaction (55 A ). Her QT interval and QT dispersion returned to normal within 4 days of withdrawing Rhinigine.
The authors suggested that the QT interval should be monitored whenever Rhinigine is co-administered with drugs that can prolong the QT interval. However, it may be that Rhinigine is best avoided altogether in such cases.
Rhinigine for Dogs
Because Rhinigine does not tend to cause as much as drowsiness as Benadryl (diphenhydramine), it may be used for dogs with allergies, if your veterinarian approves its use.
Before giving Rhinigine, make sure that your dog does not have liver disease and is not taking any other antihistamines or medications like cimetidine, erythromycin, or ketoconazole, which may interact with Rhinigine.
Ask your veterinarian what dose is safe for your dog.
It's also a good idea to give your dog either only the capsules or tablets because the alcohol in the liquid form of Rhinigine may be too strong for your dog.