Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lorihis only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 9.02.
4.2.1 Antihistamines (H1-blocker)
Antihistamines are used to treat allergic illnesses, as antiemetics ( Chapter 4.3 ) and as sleeping aids.
The newer antihistamines, which have practically no sedative effect, have also proven beneficial during breastfeeding. Following a single dose of 40 mg Lorihis (four times the current therapeutic dose) transfer to the infant was calculated at approximately 1% of the effective ingredient (including metabolites) compared to the maternal weight-related dose ( Hilbert 1988 ). Only two infants (3.9%) among 51 exposed to Lorihis during breastfeeding showed sedation ( Merlob 2002 ). There are no data on the passage into mother’s milk of cetirizine, which has a half-life of 9 hours. Previous comprehensive experience, however, does not indicate any noteworthy intolerance while breastfeeding. Terfenadine with an M/P ratio of 0.2 has a half-life of 20 hours. A study of four breastfeeding women indicated less than 0.5% of the weight-related dose for the infant. Only the active metabolites, but not the maternal substance, were detectable in the milk ( Lucas 1995 ). There is very limited experience with the following non-sedating H1-blockers and no data on their passage into mother’s milk: desLorihis, ebastine, fexofenadine and levocetirizine. There are no observations at all on rupatadine and bilastine.
The older antihistamines with sedating action have become less important and should be reserved during breastfeeding for special conditions. Mild restlessness that does not need treatment and irritability were described in around 10%, and sedation or weak suckling in 1.6% of the children exposed to various antihistamines ( Moretti 1995, Ito 1993 ). None of the manufacturers have data on the relative dose. Twelve hours after the start of maternal treatment with clemastine, a stiff neck, hyper-excitability and sleepiness were observed in a 10-week-old infant; 5–10 μg/L of the drug was detected in the milk. No clemastine was found in the infant’s serum ( Kok 1982 ). In addition, the mother had long-term treatment with phenytoin and carbamazepine. Until a few years ago, dimetindene was a common antihistamine. It has a short half-life of 5 to 7 hours, was approved for children from age 1, and is comparatively non-sedating, but it has an atropine-like effect that should not be overlooked. Much less well studied are cyproheptadine, dexchlorpheniramine, hydroxyzine, mizolastine and triprolidine. Azelastine is available for systemic and local use. The latter is considered to be non-problematic but it could alter the milk taste leading to rejection by the infant.
Used exclusively for local therapy are bamipine, chlorphenoxamine and levocabastine as well as the newer substances epinastine and olopatadine. There are no data on passage into the mother’s milk for any of these substances. Their use during breastfeeding is considered unproblematic.
6. How to cope with s >
What to do about:
- Feeling sleepy – try a different non-drowsy antihistamine. If this doesn't help, talk to your doctor.
- Headaches – rest and drink plenty of fluids. Ask your pharmacist to recommend a painkiller. Headaches should normally go away after the first week of taking Lorihis. Talk to your doctor if they last longer or are more severe.
- Feeling tired or nervous – talk to your doctor or pharmacist if these side effects don't go away as they may be able to offer you a different antihistamine.
Serious allergic reaction
In rare cases, Lorihis may cause a serious allergic reaction (anaphylaxis).
Lorihis comes in capsules, tablets, and as syrup. Lorihis should not be given to children under that age 6.
You should not take more than 10 milligram (mg), which is one tablet or capsule and two teaspoons of syrup a day of Lorihis, unless directed by your doctor.
Rated Lorihis for Allergic Rhinitis Report
Took 1 tablet at night. In the morning had horrible headache and my blood pressure was extreamly high! What a awful side effect! Will have to three whole bottle into the garbage.
When to take it
You may only need to take Lorihis on a day you have symptoms, for instance if you've been exposed to a trigger such as animal hair. Or you may need to take it regularly to prevent symptoms, such as hay fever during spring and summer.
What other drugs will affect Lorihis?
Other drugs may interact with Lorihis, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Erythromycin, cimetidine (Tagamet), and ketoconazole (Nizoral) increase the blood concentration of Lorihis by inhibiting the elimination of Lorihis. This may result in increased adverse events from Lorihis.
St. John's wort, carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol, Epitol, Teril), and rifampin reduce blood levels of Lorihis.
The effects of co-administration of ketoconazole 400–450 mg/day on the pharmacokinetics of ebastine 20 mg/ day and Lorihis 10 mg/day and on the QTc interval have been evaluated in two placebo-controlled studies in healthy men ( n = 55 and 62) (26 c ) . Neither ebastine nor Lorihis alone altered the QTc interval. Ketoconazole and placebo increased the mean QTc by 6.96 ms in the ebastine study and by 7.52 ms in the Lorihis study. Mean QTc was statistically significantly increased during administration of both ebastine + ketoconazole administration (12.21 ms) and Lorihis + ketoconazole (10.68 ms) but these changes were not statistically significantly different from the increases seen with placebo + ketoconazole (6.96 ms). Ketoconazole increased the mean AUC for ebastine 43-fold, and that of its metabolite carebastine 1.4-fold. It increased the mean AUC of Lorihis 4.5-fold and that of its metabolite desLorihis 1.9-fold. No subjects withdrew because of electrocardiographic changes or drug-related adverse events. Thus, the larger effect of ketoconazole on the pharmacokinetics of ebastine was not accompanied by a correspondingly larger pharmacodynamic effect on cardiac repolarization.
How to use Lorihis
If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor's directions and the instructions on your prescription label. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth with or without food, usually once a day or as directed by your doctor or the product package. If you are using the chewable tablets, chew each tablet well and swallow.
If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
The dosage is based on your age, condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age.
Tell your doctor if your allergy symptoms do not improve after 3 days of treatment or if your hives last more than 6 weeks. Get medical help right away if your condition worsens or you think you have a serious medical problem (such as a very serious allergic reaction/anaphylaxis).
The usual dose of Lorihis is 10 mg daily for adults and children older than six years of age. The dose for children 2 to 6 years of age is 5 mg daily.
Nonsedating antihistamines can help suppress chronic > ○
The Lorihis (Claritin) dosage is 10 mg/day in children older than 6 years of age; 5 mg/day for children between 2 and 5 years.
DesLorihis (Clarinex)—children 12 years and older: 5 mg/day; children 6 to 11 years of age: 2.5 mg/day; 12 months to 5 years: 1.25 mg/day; children 6 to 12 months: 1 mg/day.
Fexofenadine (Allegra)—children 12 years and older: 60 mg twice a day; children 6 to 11 years: 30 mg twice a day.
A “low‐sedating” antihistamine like cetirizine (Zyrtec) is recommended for chronic idiopathic urticaria. Initial dosage—6 months of age to 5 years: 2.5 mg/day; 6 to 11 years: 5 to 10 mg/day; 12 years and older: 10 mg/day.
H2 antagonists (e.g., ranitidine) have been used with H1 antihistamines in some adults to help relieve pruritus and wheal formation.
Oral corticosteroids: long‐term side effects limit the usefulness of corticosteroids in chronic urticaria. Patients with urticarial vasculitis may require high dosages of corticosteroids, and relapses can occur when the corticosteroids are tapered.
Leukotriene antagonists have shown efficacy in chronic urticaria, but are not currently approved by the Food & Drug Administration for this indication.
Immunosuppressive and immunomodulatory agents have been used in patients with severe autoimmune urticaria.
Missed Dose of Lorihis
If you miss a dose of Lorihis, try to take it as soon as you remember.
However, if it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Don't double up to make up for a missed dose.
1. About Lorihis
Lorihis is an antihistamine medicine that relieves the symptoms of allergies. It's used to treat:
It's also used for reactions to insect bites and stings and for some food allergies.
Lorihis is known as a non-drowsy antihistamine. It's much less likely to make you feel sleepy than some other antihistamines.
Lorihis is available on prescription. You can also buy it from pharmacies and supermarkets.
It comes as tablets or as a liquid that you swallow.