Loratrim tablets

Loratrim

  • Active Ingredient: Loratadine
  • 10 mg
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What is Loratrim?

The active ingredient of Loratrim brand is loratadine. Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Used for

Loratrim is used to treat diseases such as: Allergic Reactions, Allergic Rhinitis, Urticaria.

Side Effect

Possible side effects of Loratrim include: ; ; ; ; ; ; .

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Rated Loratrim for Allergic Rhinitis Report

It cleared my sinus' but I had a sleepless night.

Q: Can Loratrim medication make me gain weight or feel puffy all the time?

A: According to the available literature, weight gain and "feeling puffy" were not commonly reported side effects of Loratrim. If you have been experiencing a feeling of puffiness or unexplained changes in weight, with no changes in diet or activity level, you may want to contact your health care provider to determine the cause. For additional information regarding Loratrim you may want to visit our Web site: //www.everydayhealth.com/drugs/Loratrim.

Q: I have been getting a lot of sinus headaches and talked to my doctor who has me on some new mediciation for allergies. Will this medication also help with sinus headaches as well? If I take this every day, would that dry out my sinuses to much? I'm on Loratrim.

A: Loratrim is in a class of medications called antihistamines. Loratrim works by blocking the action of histamine, a substance made in the body that causes allergy symptoms. Sometimes sinus headaches are caused by allergies. When allergies lead to sinus headaches, an antihistamine, like Loratrim may be used. Dry nose and dry mouth are side effects reported in some patients who take Loratrim; however, Loratrim is less likely to cause these side effects compared with some other antihistamines.

How much to take

Loratrim comes as 10mg tablets and as a liquid medicine (labelled either 5mg/5ml or 1mg/1ml). You can take Loratrim with or without food.

The usual dose in adults is 10mg once a day.

Doses are usually lower for people with liver problems.

For children, your doctor will use your child's weight or age to work out the right dose.

How to use Loratrim

If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor's directions and the instructions on your prescription label. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food, usually once a day or as directed by your doctor or the product package. If you are using the chewable tablets, chew each tablet well and swallow.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your age, condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age.

Tell your doctor if your allergy symptoms do not improve after 3 days of treatment or if your hives last more than 6 weeks. Get medical help right away if your condition worsens or you think you have a serious medical problem (such as a very serious allergic reaction/anaphylaxis).

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Anti-histamines

Histamine mediates most of its effects on airway function via H1-receptors. Non-sedating potent H1 -receptor antagonists, such as terfenadine, fexafenadine, Loratrim , desLoratrim, ebastine, and astemizole, have useful clinical effects in allergic rhinitis, but they are far from effective in asthmatic patients . The effects of anti-histamines are small and clinically insignificant. Terfenadine causes about 50% inhibition of the immediate response to allergen, but has no effect on the late response . Anti-histamines cause a small degree of bronchodilatation in asthmatic patients, indicating a certain degree of histamine “tone,” presumably due to the basal release of histamine from activated mast cells . Chronic administration of terfenadine has a small clinical effect in mild allergic asthmatic patients, but is far less effective that other anti-asthma therapies. H1-receptor antagonists have not been found to be useful in more severe asthmatic patients . The new generation anti-histamines, cetirizine and astemizole, have some beneficial effects in asthma, that may be unrelated to their H1-antagonist effects .

H2-antagonists, such as cimetidine and ranitidine, may be contraindicated in asthma on theoretical grounds, if H2-receptors are important in counteracting the bronchoconstrictor effect of histamine. In clinical practice, however, there is no evidence that H2-antagonists have any deleterious effect in asthma. H3-receptor agonists may have some theoretical benefit in asthma, since they may modulate cholinergic bronchoconstriction and inhibit neurogenic inflammation. Although (R)-α-methylhistamine relaxes rodent peripheral airways in vitro, it has no effect when given by inhalation on airway caliber or metabisufite-induced bronchoconstriction in asthmatic patients, indicating that a useful clinical effect is unlikely .

Histamine H4-receptors are expressed on eosinophils, T- cells, dendritic cells, basophils and mast cells, mediate mast cell, eosinophil and dendritic cell chemotaxis, and modulate cytokine production from dendritic cells and T-cells, indicating that blockade of histamine H4-receptors may lead to anti-allergic and anti-inflammatory effects. Several histamine H4-receptor antagonists are now available but remain to be tested in allergic asthma or rhinitis . Antagonists that block both histamine H1- and H4-receptors may be an effective combination. Anti-histamines have a useful effect in the treatment of rhinitis, and particularly the rhinorrhea. As a large proportion of patients with asthma have concomitant rhinitis, an H1-antagonist may help the overall management of asthma . While H1-receptor antagonists alone may be ineffective, some studies suggest that they may have some efficacy in combination with other antagonists. Thus, an H1-receptor antagonist when added to an anti-leukotriene was able to inhibit the early and late responses to allergen more effectively than the anti-leukotriene alone , but as yet there has been no studies of combination mediator antagonists in asthma.

There is no evidence that anti-histamines have any role in the treatment of COPD.

Loratrim dosing information

Usual Adult Dose of Loratrim for Allergic Rhinitis:

10 mg orally once a day

Usual Adult Dose for Urticaria:

10 mg orally once a day

Usual Pediatric Dose for Allergic Rhinitis:

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)

Usual Pediatric Dose for Urticaria:

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Loratrim. For a full list see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.


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