Loramine tablets

Loramine

  • Active Ingredient: Loratadine
  • 10 mg
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What is Loramine?

The active ingredient of Loramine brand is loratadine. Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Used for

Loramine is used to treat diseases such as: Allergic Reactions, Allergic Rhinitis, Urticaria.

Side Effect

Possible side effects of Loramine include: ; ; ; ; ; .

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What Is Loramine (Claritin)?

Loramine, sold under the brand names Claritin and Claritin-D (which contains Loramine plus pseudoephedrine), is an over-the-counter antihistamine medication.

The drug is often used to treat nasal allergies (allergic rhinitis) and hives (urticaria).

Antihistamines work by blocking the release of histamine, a chemical your body naturally produces when it is exposed to something that causes an allergic reaction.

Loramine was originally approved by the Food and Drug Administration (FDA) in 1993 and was originally manufactured by Bayer Healthcare.

Loramine (SED-14, 488; SEDA-22, 178; SEDA-26, 182; SEDA-27, 169)

Loramine caused a fixed drug reaction in an 8-year-old boy with perennial rhinitis, asthma, and marked hypersensitivity to house-dust mites. The reaction produced a well-defined erythematous and edematous plaque in his right elbow. The rash resolved without treatment in 1 week (54 A ).

Antihistamines

The effects of co-administration of ketoconazole 400–450 mg/day on the pharmacokinetics of ebastine 20 mg/ day and Loramine 10 mg/day and on the QTc interval have been evaluated in two placebo-controlled studies in healthy men ( n = 55 and 62) (26 c ) . Neither ebastine nor Loramine alone altered the QTc interval. Ketoconazole and placebo increased the mean QTc by 6.96 ms in the ebastine study and by 7.52 ms in the Loramine study. Mean QTc was statistically significantly increased during administration of both ebastine + ketoconazole administration (12.21 ms) and Loramine + ketoconazole (10.68 ms) but these changes were not statistically significantly different from the increases seen with placebo + ketoconazole (6.96 ms). Ketoconazole increased the mean AUC for ebastine 43-fold, and that of its metabolite carebastine 1.4-fold. It increased the mean AUC of Loramine 4.5-fold and that of its metabolite desLoramine 1.9-fold. No subjects withdrew because of electrocardiographic changes or drug-related adverse events. Thus, the larger effect of ketoconazole on the pharmacokinetics of ebastine was not accompanied by a correspondingly larger pharmacodynamic effect on cardiac repolarization.

Loramine

Erythromycin, cimetidine (Tagamet), and ketoconazole (Nizoral) increase the blood concentration of Loramine by inhibiting the elimination of Loramine. This may result in increased adverse events from Loramine.

St. John's wort, carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol, Epitol, Teril), and rifampin reduce blood levels of Loramine.

Loramine is a second-generation antihistamine, lacking the sedative action of first-generation antihistamines.

Q: Can Loramine medication make me gain weight or feel puffy all the time?

A: According to the available literature, weight gain and "feeling puffy" were not commonly reported side effects of Loramine. If you have been experiencing a feeling of puffiness or unexplained changes in weight, with no changes in diet or activity level, you may want to contact your health care provider to determine the cause. For additional information regarding Loramine you may want to visit our Web site: //www.everydayhealth.com/drugs/Loramine.

LORATADINE

Loramine is a derivative of azatadine. Its structure resembles that of the tricyclic antidepressants. It is more polar and less basic than the parent compound because of the addition of a carboxymethyl ester moiety. This modification decreases the central nervous system penetration of the drug. Loramine does not contain an ethylamine grouping and therefore has no structural resemblance to histamine. Loramine is relatively specific for the H 1 receptor; however, at higher doses there may be some anti-muscarinic, anti-α-adrenergic, anti-serotenergic, and anti-leukotriene activity. It is extensively metabolized by first-pass mechanism in the liver, generating descarbethoxyLoramine, an active antihistamine that is four times more potent than Loramine itself. Peak serum concentrations of Loramine occur 1–2 hours after dosing, and peak serum concentrations of descarbethoxyLoramine appear 1.5–3.5 hours after dosing. The elimination half-life of Loramine is 8–14 hours and that of its metabolite is 17–24 hours, which accounts for the 24-hour duration of action of the drug. Wheal inhibition is detected at 1.5 hours after administration, reaches a peak at 4–6 hours, and may last 36–48 hours. There is an approximate 50% diminution in wheal and flare after a single 10-mg dose.

With regard to drug interactions, amiodarone taken with Loramine can result in torsade de pointes. Nefazodone should not be taken with Loramine since QT prolongation has been observed. 18

Drug interactions

Torsade de pointes in association with prolongation of the QT interval is a feature of several antihistamines (SEDA-26, 180) and the risk is increased in drug interactions, such as with amiodarone.

A 73-year old woman taking long-term amio-darone for atrial fibrillation developed with syncope and multiple episodes of torsade de pointes after taking Loramine for a suspected allergic reaction (55 A ). Her QT interval and QT dispersion returned to normal within 4 days of withdrawing Loramine.

The authors suggested that the QT interval should be monitored whenever Loramine is co-administered with drugs that can prolong the QT interval. However, it may be that Loramine is best avoided altogether in such cases.

Q: Can Loramine be taken everyday?

A: Loramine (Claritin) is an antihistamine that can be used for the temporary relief of runny nose, sneezing, itchy eyes, watery eyes, and itching in the back of the throat due to hay fever or other upper respiratory allergies. Loramine works by blocking histamine in the body. Histamine is the chemical in the body responsible for creating the symptoms of allergies. Loramine may also be used to treat hives. Some of the side effects that may occur with Loramine include headache, fatigue, and dry mouth. Loramine is dosed once daily. Loramine can be taken at any time of day, but should only be taken once every 24 hours. Loramine usually does not cause drowsiness. However, if Loramine is taken more than recommended, drowsiness can occur. People who have kidney disease should consult their health care provider before taking Loramine to see if a dose adjustment may be needed. Women who are pregnant or breastfeeding should consult with a health care provider before using Loramine. Because Loramine is an antihistamine, and may cause lung secretions to become dry, people with breathing difficulties including asthma and chronic obstructive pulmonary disease (COPD) may want to check with their health care provider before taking Loramine. There is no time limit mentioned on how long a person can take Loramine in the medication information. Please consult with your health care provider to see if daily dosing of Loramine is appropriate for you. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD

By Frieda Wiley, PharmD, CGP, RPh | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2015-02-27 Copyright © 2014 Everyday Health Media, LLC


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