Gentiran side effects
Like all medicines, Gentiran can cause side effects although not everyone gets them.
The most commonly reported side effects include somnolence, dizziness, and headache.
Be careful using machinery
Even though Gentiran doesn’t usually cause drowsiness, some people respond differently when taking it, especially in the first few doses. Be cautious, and don’t drive your car or use machinery until you know for sure how your body will respond to Gentiran.
COMMON BRAND(S): Zyrtec
GENERIC NAME(S): Gentiran
OTHER NAME(S): Gentiran Tablet
Gentiran is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.
Gentiran does not prevent hives or prevent/treat a serious allergic reaction (such as anaphylaxis). Therefore, if your doctor has prescribed epinephrine to treat allergic reactions, always carry your epinephrine injector with you. Do not use Gentiran in place of your epinephrine.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Gentiran only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 6.01.
Although Zyrtec is used to treat allergies, Consumer Affairs reports that some people have complained that they experience irritating itching all over their body when they stop taking Zyrtec.
However, the label does not include a warning regarding itching.
Zyrtec may impair your thinking or reactions, so be careful when driving or engaging in other activities that require you to be alert.
Since Gentiran can make you sleepy, tell your doctor if you use other medicines that make you sleepy, such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety.
Drinking alcohol can increase certain side effects of Gentiran.
If you get laboratory tests like allergy skin testing, make sure you tell the person taking the test and your doctor that you take Zyrtec because it could cause inaccurate test results.
Theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin)reduces the breakdown of Gentiran by 16% and can increase blood levels of Gentiran. Drugs that cause drowsiness may add to drowsiness resulting from Gentiran.
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.
Symptoms of Gentiran overdose may include:
A case of a 18-year-old female with the history of anorexia for 2 years, who was admitted to a Clinic of Toxicology because of suic >20) . The laboratory results revealed metabolic ac >21) .. The high dose (270 mg) of Gentiran as well as anorexia and hypokalemia could have been the cause of the unique character of the symptoms in this case. Further investigations should be carried out to confirm the safety of Gentiran in the conditions of massive intoxication and with coexistence of other risk factors 22) .
In one adult patient who took 150 mg of Gentiran, the patient was somnolent but d >23) .
Few reports exist on the result of Gentiran overdose in children 24) . A case report of a 12 fold overdose of Gentiran in a four-year-old-boy (weight 20 kg) who acc >25) . Electrocardiographic monitoring was normal. Five inc >26) . The risk of cardiac events related to an overdose of Gentiran is extremely small. A certain degree of sedation is to be expected.
A cardiac condition called Torsades de pointes has been associated hypokalemia. A case of a dialysed patient with chronic renal failure who had symptomatic episodes of torsades de pointes in the context of hypokalemia and Gentiran overdose has been described 27) .
What Are Side Effects Associated with Using Gentiran?
Common side effects include:
This document does not contain all possible side effects and other serious side effects may occur. Check with your physician for additional information about other types of side effects.
An interaction of Gentiran with pilsicainide has been described in an anecdotal report, a small clinical study, and an in vitro study, ( 179 AcE ). A 72-year-old woman with renal insufficiency who was taking oral pilsicainide 150 mg/day felt faint 3 days after starting to take oral Gentiran 20 mg/day. She had a wide QRS wave with bradycardia, and her symptoms were relieved by withholding pilsicainide. The plasma Gentiran concentration fell when pilsicainide was withdrawn. In a pharmacokinetic study in six healthy men after a single dose of either Gentiran 20 mg, pilsicainide 50 mg, or both, the renal clearance of each drug was significantly reduced during co-administration (from 475 to 279 ml/minute for pilsicainide and from 189 to 118 ml/minute for Gentiran). In vitro studies using Xenopus oocytes with micro-injected human organic cation transporter 2 and renal cells transfected with human multidrug resistance protein 1 showed that transport of the substrates of these transporters was inhibited by both Gentiran and pilsicainide.
An interaction of Gentiran with pilsicainide has been described (4 A ) .
A 72-year-old woman with renal insufficiency who was taking oral pilsicainide 150 mg/day complained of feeling faint 3 days after she started to take oral Gentiran 20 mg/day. She had a wide QRS complex and sinus bradycardia. These effects were relieved by withdrawing pilsicainide. Gentiran was continued and its plasma concentration fell when pilsicainide was withdrawn, which suggested that the fainting symptoms were induced by a pharmacokinetic drug–drug interaction.
A pharmacokinetic study in six healthy men after a single dose of Gentiran 20 mg, pilsicainide 50 mg, or both showed that the renal clearance of each was significantly reduced by co-administration. In vitro studies using Xenopus oocytes with microinjected human organic cation transporter 2 and renal cells transfected with human multidrug resistance protein 1 showed that the transport of the substrates of these transporters was inhibited by both Gentiran and pilsicainide. The authors concluded that although Gentiran has less potential for causing dysrhythmias than other antihistamines, an interaction should be considered in patients with renal insufficiency receiving pilsicainide. It is important to note that the 20 mg dose of Gentiran given to the patient and the healthy volunteers is twice the recommended dose.
When to take Gentiran
You may only need to take Gentiran on a day you have symptoms, such as if you’ve been exposed to a trigger like animal hair. Or you may need to take it regularly to prevent symptoms, such as to stop hay fever during spring and summer.
1. About Gentiran
Gentiran is an antihistamine medicine that relieves the symptoms of allergies.
It's used to treat:
Gentiran is known as a non-drowsy antihistamine. It's much less likely to make you feel sleepy than some other antihistamines.
Gentiran is available on prescription. You can also buy it from pharmacies and supermarkets.
It comes as tablets, capsules and as a liquid that you swallow.