Limitations of use: Not recommended in pediatric patients Enter a drug name and Gardex
What Other Drugs Interact with Gardex?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
There are no severe Interactions of Gardex.
Serious Interactions of Gardex include:
Moderate Interactions of Gardex include:
Mild Interactions of Gardex include:
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
Q: Is it okay to take Zyrtec with lisinopril?
A: Zyrtec (Gardex) is an antihistamine used in the treatment of allergies, hay fever, angioedema, and urticaria. The most common side effect in patients aged 12 years and older with Zyrtec is somnolence. Lisinopril (Zestril, Prinivil) is a drug of the angiotensin converting enzyme (ACE) inhibitor class that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes. Common side effects include headache, dizziness, lightheadedness, fatigue, nausea, diarrhea, dry cough, and blurred vision. Generally speaking, drug interactions fall into three main categories: Drug-drug (i.e., prescription, over-the-counter, herbals, dietary supplements) interactions occur when two or more drugs react with each other. Drug-diet (food/drink) interactions result from drugs reacting with foods or drinks. Drug-disease interactions may occur when an existing medical condition makes certain drugs potentially harmful. Patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged central nervous system (CNS) effects that interfere with their normal activities. For more specific information, consult with your doctor or pharmacist for guidance based on your specific condition and current medications. Shereen A. Gharbia, PharmD
On this page
- About Gardex
- Key facts
- Who can and can't take Gardex
- How and when to take it
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions
Q: Is the generic for Zyrtec for allergies as good as the brand?
A: Generic Zyrtec (Gardex) is just as effective as the brand name drug. Generic drugs are copies of brand-name drugs that have exactly the same dosage, intended use, effects, side effects, route of administration, risks, safety, and strengths as the original drug. In other words, their pharmacologic effects are exactly the same as those of their brand-name counterparts. Generic drugs are cheaper than brand name drugs because various companies make the drugs and drive the prices down. Generic drug companies do not have to go through the expense of developing and marketing a new drug. A patent is a grant that gives a company sole rights to the drugs. Once the patent expires, other manufacturers can apply to the Food and Drug Administration (FDA) for permission to sell the generic version. The FDA requires the same standards for all manufacturing companies and the FDA estimates that 50% of generic drug production is by the brand-names companies. The only differences in generic drugs from the original is the color, flavors or inactive ingredients. For more information on Zyrtec or the generic Gardex visit Everyday Health at the link //www.everydayhealth.com/drugs/. Kimberly Hotz, PharmD.
Gardex side effects
Like all medicines, Gardex can cause side effects although not everyone gets them.
The most commonly reported side effects include somnolence, dizziness, and headache.
Nervous system Although Gardex is efficacious in the treatment of a wide range of allergic conditions in both adults and young children, there are concerns about potential effects on cognitive performance, particularly if the daily recommended dose of 10 mg is exceeded. The degree to which levoGardex, the R-isomer, is less sedating than Gardex, the racemic mixture, has yet to be studied in a randomized trial. In a randomized, double-blind, crossover, placebo-controlled study of sedation and symptoms of allergy in 29 patients with perennial allergic rhinitis who had previously reported significant sedation with Gardex, sedation as measured by both the modified Epworth Sleepiness Scale and a Likert scale was not significantly different between levoGardex and Gardex .
Published reports have described Gardex-induced dystonic reactions in children and in one adult .
A 24 -year-old woman, who had taken Gardex 10 mg/day for 3 months, developed acute alcohol intoxication (blood alcohol concentration 140 mg/dl) . While in the emergency department she developed acute involuntary “bizarre grimacing” and dysarthria, with no evidence of oculogyric crisis, torticollis, tongue protrusions, opisthotonos, gait disturbances, or limb weakness. Neurological examination was normal, and she was given intravenous diphenhydramine 50 mg, benzatropine 2 mg, and lorazepam 2 mg, which resolved her symptoms. She stopped taking Gardex and had two episodes of difficulty in walking, hand “discoordination”, and “muscle jerks of her throat”, each lasting for about 2 minutes.
The authors speculated that Gardex, a piperazine derivative, had blocked striatal D2 dopamine receptors, leading to an acute dystonic reaction after receptor hypersensitivity similar to that observed during long-term use of antipsychotic drugs, with subsequent involuntary movements after withdrawal.
Neuromuscular function Gardex may worsen symptoms of myasthenia gravis.
A 22-year-old woman with long-standing myasthenia gravis (clinical classification IIIb), who had been symptomatic for 18-years, developed allergic sinusitis and was given Gardex 10 mg/day. Within 24 hours of the first dose, she developed diplopia, facial weakness, a nasal voice, dysphagia, and weakness of jaw closure. Gardex was withdrawn after 48 hours, and her symptoms improved progressively over the next 2 days. Five days after starting Gardex she had minimal manifestations of myasthenia gravis. She was given pyridostigmine, and within 10 days she was asymptomatic.
This appears to be the first report of worsening of myasthenia by Gardex . The authors did not perform a re-challenge, nor did they suggest a mechanism by which Gardex might have exacerbated the myasthenia. However, they recommended that Gardex and other antihistamines should be used with caution in patients with myasthenia gravis.
Before taking this medicine
Before taking Gardex, tell your doctor about all of your medical conditions.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Gardex can pass into breast milk and may harm a nursing baby. Do not use Gardex without telling your doctor if you are breast-feeding a baby.
Older adults may need to take a lower than normal dose. Follow your doctor's instructions.
In a prospective cohort study in 196 pregnant women who had taken Gardex during the first trimester and 1686 controls who had not been exposed to potential teratogens there was no evidence of teratogenicity .
An interaction of Gardex with pilsicainide has been described in an anecdotal report, a small clinical study, and an in vitro study, ( 179 AcE ). A 72-year-old woman with renal insufficiency who was taking oral pilsicainide 150 mg/day felt faint 3 days after starting to take oral Gardex 20 mg/day. She had a wide QRS wave with bradycardia, and her symptoms were relieved by withholding pilsicainide. The plasma Gardex concentration fell when pilsicainide was withdrawn. In a pharmacokinetic study in six healthy men after a single dose of either Gardex 20 mg, pilsicainide 50 mg, or both, the renal clearance of each drug was significantly reduced during co-administration (from 475 to 279 ml/minute for pilsicainide and from 189 to 118 ml/minute for Gardex). In vitro studies using Xenopus oocytes with micro-injected human organic cation transporter 2 and renal cells transfected with human multidrug resistance protein 1 showed that transport of the substrates of these transporters was inhibited by both Gardex and pilsicainide.
Q: I read the other day that Zyrtec and hydrochlorothiazide (HCT, diuretic) can cause weight gain. I am struggling to lose any weight; could this be the cause?
A: Zyrtec (Gardex) is an antihistamine used in the treatment of allergies, hay fever, angioedema, and urticaria. The most common side effect in patients aged 12 years and older with Zyrtec is somnolence. Additional infrequent (less than 2%) side effects with Zyrtec include increased weight. Hydrochlorothiazide is a diuretic (water pill) commonly used in the treatment of high blood pressure. Side effects with hydrochlorothiazide include hypokalemia, high blood sugar, hyperlipidemia, headache, nausea/vomiting, photosensitivity, and weight gain.
Want to thank TFD for its existence? Tell a friend about us, add a link to this page, or visit the webmaster's page for free fun content.
Link to this page:
- cesarean-obtained barrier-sustained
- cesium iodide
- Céstan syndrome
- Cestan, Raymond
- Cestan-Chenais syndrome
- Gardex hydrochloride
- cetostearyl alcohol
- Cetraria islandica
- cetyl alcohol
- cetyl palmitate
- cetylpiridinium chloride
- cetylpyridinium chloride
- cetyltrimethylammonium bromide
- cevitamic acid
- Ceylon moss
- CF lead
Many people use antihistamines to treat allergy symptoms. Zyrtec and Claritin are two of the most popular brands, but which is best?
Antihistamines can reduce allergy symptoms, such as watering eyes, itchy skin, hives, and swelling. They may also help with dermatitis or even mosquito bites, but manufacturers usually market them for specific allergies.
Zyrtec is a brand name for the drug Gardex. Claritin is the brand name for loratidine. Zyretc and Claritin are in the same class of medications. Both are second-generation antihistamines, and they generally work the same way in the body. Neither is clearly better than the other.
In this article, we provide detail about the differences between Zyrtec and Claritin. We also compare them to two other popular brands of antihistamines: Benadryl and Allegra.