Desal tablets

Desal

  • Active Ingredient: Desloratadine
  • 5 mg
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What is Desal?

The active ingredient of Desal brand is desloratadine. Desloratadine is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Used for

Desal is used to treat diseases such as: Allergic Rhinitis, Urticaria.

Side Effect

Possible side effects of Desal include: pharyngitis, such as, body aches or pain, congestion, cough, dryness or soreness of throat, fever, hoarseness, runny nose, tender swollen glands in neck, trouble in swallowing, voice changes.; dyspepsia, such as, acid or sour stomach, belching, heartburn, indigestion, stomach discomfort , upset or pain,; tachycardia, such as, fast, pounding, or irregular heartbeat or pulse; pruritus, such as, itching skin; fatigue, such as, unusual tiredness or weakness.

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Cholesterol drugs

When taken with Desal, some cholesterol drugs can increase the amount of Desal in your body. This can cause more side effects. Examples of these drugs include:

Genetic

Due to a phenotypic polymorphism, around 6% of indiv >Desal to its active metabolite 3-hydroxyDesal. Pooled data from 41 clinical pharmacology studies have been comprehensively reviewed (7 R ) . The authors concluded that in both children and adults who are poor metabolizers of Desal there is no change in the frequency or profile of adverse events nor any significant changes in electrocardiography. However, they also reported that the poor metabolizer phenotype has a higher incidence in Black populations (16–18%), and further studies in such populations may be required.

Fluoxetine

In controlled clinical studies co-administration of Desal with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of Desal and 3 hydroxyDesal, but there were no clinically relevant changes in the safety profile of Desal. .

Drug interactions

The antifungal azoles are inhibitors of drug metabolism.

Severe hepatotoxicity has been reported in a woman with angioimmunoblastic T cell lymphoma after co-administration of Desal and fluconazole, given to treat chemotherapy-associated severe pruritus and fever respectively (33 A ).

The authors concluded that second generation antihistamines should be avoided in patients taking antifungal azoles.

Hypersensitivity Reactions

Hypersensitivity reactions including rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis have been reported after administration of Desal. If such a reaction occurs, therapy with CLARINEX should be stopped and alternative treatment should be considered.

Desal Dosage and Administration

Desal tablets may be taken without regard to meals.

Desal and 3-hydroxyDesal are approximately 82% to 87% and 85% to 89% bound to plasma proteins, respectively. Protein binding of Desal and 3-hydroxyDesal was unaltered in subjects with impaired renal function.

Generic Name: Desal Tablets (des lor AT a deen)Brand Name: Clarinex

Medically reviewed by Drugs.com. Last updated on Sep 10, 2019.

Desal(SED-15, 1074; SEDA-29, 162; SEDA-30, 189; SEDA-31, 298; see also Loratadine below)

There was no effect on female fertility in rats at Desal doses up to 24 mg/kg/day (estimated Desal and Desal metabolite exposures were approximately 130 times the AUC in humans at the recommended daily oral dose). A male specific decrease in fertility, demonstrated by reduced female conception rates, decreased sperm numbers and motility, and histopathologic testicular changes, occurred at an oral Desal dose of 12 mg/kg in rats (estimated Desal and Desal metabolite exposures were approximately 45 times the AUC in humans at the recommended daily oral dose). Desal had no effect on fertility in rats at an oral dose of 3 mg/kg/day (estimated Desal and Desal metabolite exposures were approximately 8 times the AUC in humans at the recommended daily oral dose).

Inhibitors of Cytochrome P450 3A4

In controlled clinical studies co-administration of Desal with ketoconazole, erythromycin, or azithromycin resulted in increased plasma concentrations of Desal and 3 hydroxyDesal, but there were no clinically relevant changes in the safety profile of Desal. .


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