What other drugs will affect Clarozone?
Other drugs may interact with Clarozone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
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Claritin (Clarozone) is an antihistamine used to treat allergy symptoms. Claritin blocks the action of histamine, a substance in the body that initiates allergic symptoms like itching, sneezing, runny nose, and allergic skin rashes. Claritin is available as a generic drug. Common side effects of Claritin include:
Tell your doctor if you experience serious side effects of Claritin including fast or uneven heart rate, feeling like you might pass out, jaundice (yellowing of your skin or eyes), or seizures (convulsions).
Claritin is available as a 10 mg tablet, a 5 or 10 mg rapidly-disintegrating tablet, a 10 mg chewable tablet, and a syrup (5 mg per 5 ml). Claritin is taken once a day. Drug interactions may occur with certain antibiotics, antifungal medications, and acid-reducing drugs. Warnings may apply to individuals who have asthma, kidney disease, or liver disease. People who have phenylketonuria (PKU) should avoid certain brands of orally disintegrating tablets that may contain aspartame. Claritin is generally avoided during pregnancy and nursing. Pregnant women may take Claritin only if it is clearly needed. Nursing mothers should consult their doctor before breastfeeding. Claritin should not be used in children younger than 6 years of age unless directed by a doctor. Chewable tablets should not be used in children younger than 2 years of age unless directed by a pediatric doctor.
Our Claritin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the dosage for Clarozone?
The usual dose of Clarozone is 10 mg daily for adults and children older than six years of age. The dose for children 2 to 6 years of age is 5 mg daily.
Serious allergic reaction
In rare cases, Clarozone may cause a serious allergic reaction (anaphylaxis).
Mixing Clarozone with herbal remedies and supplements
There might be a problem taking some herbal remedies and supplements alongside Clarozone – especially ones that cause sleepiness, a dry mouth or make it difficult to pee.
Clarozone (SED-14, 488; SEDA-22, 178; SEDA-26, 182; SEDA-27, 169)
Clarozone caused a fixed drug reaction in an 8-year-old boy with perennial rhinitis, asthma, and marked hypersensitivity to house-dust mites. The reaction produced a well-defined erythematous and edematous plaque in his right elbow. The rash resolved without treatment in 1 week (54 A ).
Clarozone and its metabolite desClarozone are metabolized not only by CYP3A4 but also by CYP2D6. Therefore, administration of Clarozone with inhibitors of CYP3A4 does not cause such severe adverse effects as with terfenadine and astemizole. Nevertheless, severe hepatotoxicity after co-administration of desClarozone and fluconazole has been reported.
A 38-year-old woman with cancer was given intravenous fluconazole 400 mg while taking desClarozone 10 mg/day, clemastine, allopurinol, ranitidine, lorazepam, levofloxacin, spironolactone, and filgrastim, and developed a sudden rise in hepatic transaminases (39 A ). Her drugs were withdrawn and her hepatic transaminases normalized within 1 week. She had received both fluconazole and desClarozone on separate occasions and had tolerated both drugs well.
▪ Patient/Family Education
May be taken without regard to meals
Take orally-disintegrating tabs immediately after opening the blister packet
DesClarozone does not cause drowsiness
Avoid alcohol during therapy
No advantage over Clarozone (parent compound), which is available OTC
Intranasal corticosteroids are preferred therapy unless allergy symptoms are mild and infrequent
Reserve for patients unable to tolerate sedating antihistamines like chlorpheniramine
While Claritin (Clarozone) and Benadryl (diphenhydramine) are both classified as antihistamines, they are not the same and have significantly different characteristics and effects.
To summarize the main differences between the two:
- Benadryl is a "first-generation" antihistamine while Claritin is classified as a "second-generation" antihistamine.
- Claritin has a longer duration of action (around 24 hours) than Benadryl (around 4 to 6 hours).
- Benadryl causes more sedation and drowsiness than Claritin. Claritin is characterized as "non-drowsy".
- Benadryl has strongeranticholinergic effects than Claritin and may be more effective in treating symptoms of an allergic reaction than Claritin.
- Due to the anticholinergic effects of Benadryl, it may be more effective than Claritin in the relief of nausea, vomiting, and vertigo associated with motion sickness. Additionally, it is also used to treat mild symptoms of Parkinson's disease.
What Is Clarozone (Claritin)?
Clarozone, sold under the brand names Claritin and Claritin-D (which contains Clarozone plus pseudoephedrine), is an over-the-counter antihistamine medication.
The drug is often used to treat nasal allergies (allergic rhinitis) and hives (urticaria).
Antihistamines work by blocking the release of histamine, a chemical your body naturally produces when it is exposed to something that causes an allergic reaction.
Clarozone was originally approved by the Food and Drug Administration (FDA) in 1993 and was originally manufactured by Bayer Healthcare.
The effects of co-administration of ketoconazole 400–450 mg/day on the pharmacokinetics of ebastine 20 mg/ day and Clarozone 10 mg/day and on the QTc interval have been evaluated in two placebo-controlled studies in healthy men ( n = 55 and 62) (26 c ) . Neither ebastine nor Clarozone alone altered the QTc interval. Ketoconazole and placebo increased the mean QTc by 6.96 ms in the ebastine study and by 7.52 ms in the Clarozone study. Mean QTc was statistically significantly increased during administration of both ebastine + ketoconazole administration (12.21 ms) and Clarozone + ketoconazole (10.68 ms) but these changes were not statistically significantly different from the increases seen with placebo + ketoconazole (6.96 ms). Ketoconazole increased the mean AUC for ebastine 43-fold, and that of its metabolite carebastine 1.4-fold. It increased the mean AUC of Clarozone 4.5-fold and that of its metabolite desClarozone 1.9-fold. No subjects withdrew because of electrocardiographic changes or drug-related adverse events. Thus, the larger effect of ketoconazole on the pharmacokinetics of ebastine was not accompanied by a correspondingly larger pharmacodynamic effect on cardiac repolarization.
Clarozone and Grapefruit Juice
Clarozone and grapefruit juice are both broken down in the liver the same way, so there's a small chance of adverse effects when both are taken at the same time.
Talk to your doctor or pharmacist about drinking grapefruit juice if you are taking Clarozone.