APC-Loratadine tablets


  • Active Ingredient: Loratadine
  • 10 mg
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What is APC-Loratadine?

The active ingredient of APC-Loratadine brand is loratadine. Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Used for

APC-Loratadine is used to treat diseases such as: Allergic Reactions, Allergic Rhinitis, Urticaria.

Side Effect

Possible side effects of APC-Loratadine include: ; ; ; ; ; ; ; .

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Q: I have been waking up with headaches since being put on Alavert. Should I tell my doctor?

A: Headaches are a frequently occurring, minor side effect associated with Alavert (APC-Loratadine) treatment. It is always a good idea to check with your health care provider if you experience bothersome side effects from a medication. Your doctor may be able to recommend a change in the time of dosage or possibly add a headache medicine to your regimen. Please consult your health care provider for further guidance in your specific case. //www.everydayhealth.com/drugs/APC-Loratadine Gregory Latham, RPh

▪ Patient/Family Education

May be taken without regard to meals

Take orally-disintegrating tabs immediately after opening the blister packet

DesAPC-Loratadine does not cause drowsiness

Avoid alcohol during therapy

Common side effects

The most common side effect of APC-Loratadine is feeling sleepy. This happens in more than 1 in 100 people.

Side effects in children may include:

  • headaches
  • feeling tired
  • feeling nervous

Montelukast (SEDA-24, 184; SEDA-26, 193; SEDA-27, 179)

The activity and safety of montelukast have been assessed in 1214 patients with spring seasonal allergic rhinitis taking montelukast 10 mg (n = 522), APC-Loratadine 10 mg ( n = 171), or placebo (n = 521) daily at bedtime for 2 weeks in a randomized, double-blind, placebo-controlled trial (65 C ). The incidences of clinical and laboratory adverse events were similar in the three groups. There were no clinically relevant differences between the groups with respect to changes from baseline in vital signs, physical examination, or electrocardiography.

Why is this medication prescribed?

APC-Loratadine is used to temporarily relieve the symptoms of hay fever (allergy to pollen, dust, or other substances in the air) and other allergies. These symptoms include sneezing, runny nose, and itchy eyes, nose, or throat. APC-Loratadine is also used to treat itching and redness caused by hives. However, APC-Loratadine does not prevent hives or other allergic skin reactions. APC-Loratadine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.

APC-Loratadine is also available in combination with pseudoephedrine (Sudafed, others). This monograph only includes information about the use of APC-Loratadine alone. If you are taking the APC-Loratadine and pseudoephedrine combination product, read the information on the package label or ask your doctor or pharmacist for more information.


The effects of co-administration of ketoconazole 400–450 mg/day on the pharmacokinetics of ebastine 20 mg/ day and APC-Loratadine 10 mg/day and on the QTc interval have been evaluated in two placebo-controlled studies in healthy men ( n = 55 and 62) (26 c ) . Neither ebastine nor APC-Loratadine alone altered the QTc interval. Ketoconazole and placebo increased the mean QTc by 6.96 ms in the ebastine study and by 7.52 ms in the APC-Loratadine study. Mean QTc was statistically significantly increased during administration of both ebastine + ketoconazole administration (12.21 ms) and APC-Loratadine + ketoconazole (10.68 ms) but these changes were not statistically significantly different from the increases seen with placebo + ketoconazole (6.96 ms). Ketoconazole increased the mean AUC for ebastine 43-fold, and that of its metabolite carebastine 1.4-fold. It increased the mean AUC of APC-Loratadine 4.5-fold and that of its metabolite desAPC-Loratadine 1.9-fold. No subjects withdrew because of electrocardiographic changes or drug-related adverse events. Thus, the larger effect of ketoconazole on the pharmacokinetics of ebastine was not accompanied by a correspondingly larger pharmacodynamic effect on cardiac repolarization.


APC-Loratadine and its metabolite desAPC-Loratadine are metabolized not only by CYP3A4 but also by CYP2D6. Therefore, administration of APC-Loratadine with inhibitors of CYP3A4 does not cause such severe adverse effects as with terfenadine and astemizole. Nevertheless, severe hepatotoxicity after co-administration of desAPC-Loratadine and fluconazole has been reported.

A 38-year-old woman with cancer was given intravenous fluconazole 400 mg while taking desAPC-Loratadine 10 mg/day, clemastine, allopurinol, ranitidine, lorazepam, levofloxacin, spironolactone, and filgrastim, and developed a sudden rise in hepatic transaminases (39 A ). Her drugs were withdrawn and her hepatic transaminases normalized within 1 week. She had received both fluconazole and desAPC-Loratadine on separate occasions and had tolerated both drugs well.

How to take APC-Loratadine

  • Before starting the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about APC-Loratadine dosage, and it will also provide you with a full list of side-effects which could be experienced from taking it.
  • For adults and for children aged over 12 years: 10 mg taken once a day.
  • For children aged over 2 years weighing 31 kg or more: 10 mg taken once a day.
  • For children aged over 2 years weighing less than 31 kg: 5 mg taken once a day.
  • If you are giving APC-Loratadine liqu >

    APC-Loratadine Interactions

    APC-Loratadine is not known to have many major drug interactions.

    However, it's still important to share with your doctor and pharmacist all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking.

    You should not take APC-Loratadine if you are taking Ranexa (ranolazine).

    Also, before taking APC-Loratadine, first talk to your doctor if you are taking any of the following:

    • Cordarone, Nexterone, or Pacerone (amiodarone)
    • Prezista (darunavir)
    • Sprycel (dasatinib)

    APC-Loratadine and Alcohol

    Because both alcohol and APC-Loratadine may cause drowsiness, along with dry mouth and dry eyes (which may blur vision), you should avoid drinking alcohol while taking APC-Loratadine.

    Q: I have been waking up with headaches since being put on Alavert. Should I tell my doctor?

    A: Your question concerns possible side effects of Alavert . (//www.everydayhealth.com/drugs/APC-Loratadine) Headaches are a frequently occurring minor side effect of Alavert. It is always a good idea to check with one It is always a good idea to check with one..

    Immediate action required: Call 999 or go to A&E if:

    • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
    • you're wheezing
    • you get tightness in the chest or throat
    • you have trouble breathing or talking
    • your mouth, face, lips, tongue or throat start swelling

    You could be having a serious allergic reaction and may need immediate treatment in hospital.

    These are not all the side effects of APC-Loratadine. For a full list see the leaflet inside your medicines packet.

    You can report any suspected side effect to the UK safety scheme.

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    What is the difference between cetirizine and APC-Loratadine?

    • Cetirizine and APC-Loratadine are non-sedating antihistamines used to treat symptoms of allergic reaction such as symptoms of seasonal hay fever (allergic rhinitis) such as sneezing, runny nose, red/watery/itchy eyes, hives, and allergic skin rash.
    • Brand names for Cetirizine include Zyrtec, Zyrtec Allergy, and Zyrtec Hives Relief. Brand names for APC-Loratadine include Claritin, Claritin RediTabs, Alavert, Claritin Hives Relief, Children's Claritin, and others.
    • Both cetirizine and APC-Loratadine are available over-the-counter (OTC) and in generic form.
    • Side effects of cetirizine and APC-Loratadine that are similar include drowsiness, dry mouth, headache, and fatigue.
    • Side effects of cetirizine that are different from APC-Loratadine include nausea, jitteriness, and sore throat.
    • Side effects of APC-Loratadine that are different from cetirizine include nervousness and difficulty sleeping.

    6. How to cope with s >

    What to do about:

    • Feeling sleepy – try a different non-drowsy antihistamine. If this doesn't help, talk to your doctor.
    • Headaches – rest and drink plenty of fluids. Ask your pharmacist to recommend a painkiller. Headaches should normally go away after the first week of taking APC-Loratadine. Talk to your doctor if they last longer or are more severe.
    • Feeling tired or nervous – talk to your doctor or pharmacist if these side effects don't go away as they may be able to offer you a different antihistamine.

    Dictionary Entries near APC-Loratadine

    Cite this Entry

    “APC-Loratadine.” The Merriam-Webster.com Medical Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/medical/APC-Loratadine. Accessed 26 December 2019.

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